CDC’s Division of HIV Prevention just lately released 5 notices of funding option (NOFO) for investigate routines on quite a few vital concerns in HIV avoidance.
The funding possibilities are aligned with Nationwide HIV/AIDS Approach (NHAS) priorities and aid the implementation of the Ending the HIV Epidemic in the U.S. (EHE) initiative. Aspects on every single chance with deadlines and backlinks for additional information are provided below.
Extensive-Acting Antiretroviral Treatment Choices among the Black Ladies
Checking out Tastes for Lengthy-Acting Antiretroviral Therapies (LA-Artwork) in a Group-Dependent Sample of Priority Populations Living with HIV Who are Disproportionately Affected will help formative exploration on acceptance and perceived obstacles and facilitators of working with latest and upcoming LA-Artwork among the cis-gender Black females with HIV (CgBWH). Developing equitable obtain to HIV treatment method and treatment for folks with HIV involves successful uptake of new and emerging treatment plans, this sort of as LA-Artwork, which provide pros these kinds of as convenience and lowered stigma in comparison to every day oral cure. Inequities in HIV contain the disproportionate level of HIV amid CgBWH. CgBWH account for approximately 60% of new HIV infections in U.S. women of all ages, regardless of generating up significantly less than 15% of the feminine inhabitants. Due to a host of social determinants of well being (SDOH) like racism, poverty, stigma, unequal accessibility to wellness care, and housing and educational inequities, CgBWH bear the highest burden of HIV an infection amongst U.S. ladies. Presented this disproportionate level of infection and connected SDOH, the focus populace of this NOFO is CgBWH. This NOFO supports the EHE initiative “Treat” pillar. Precisely, the EHE program lists CgBWH as a precedence populace to target on for avoidance, treatment, and procedure interventions and means for the finest influence in reaching the NHAS plans.
For additional facts, watch CDC’s site on NOFO PS23-003. Programs are due on 03/17/2023 and can be accessed from grants.gov.
Quick Art Initiation in the Unexpected emergency Department
Growing Immediate Initiation of Antiretroviral Treatment (Art) in Non-standard Configurations: Crisis Office will assist implementation research on the swift or rapid initiation of Art for persons recently identified with HIV or for folks with HIV returning to treatment in unexpected emergency department (ED) settings. Fast initiation of Art is advisable for any person newly identified with HIV, regardless of CD4 count. The fast Art design, defined as speedy analysis, linkage to care, and Artwork initiation on the exact same day as a new HIV analysis or return to care, should present an accelerated entry into HIV clinical treatment. Speedy Art confers a better price of engagement in treatment, cuts down the time to viral suppression, and increases morbidity and mortality in individuals with HIV. The ED presents a one of a kind setting to right away have interaction with patients who are not accessing HIV treatment products and services. The implementation exploration supported by this funding will deploy immediate Art versions in ED settings and consider acceptability, perceived limitations and facilitators, feasibility, sustainability, and HIV care continuum outcomes. Applied study resulting from this funding is predicted to decrease HIV bacterial infections and promptly reach viral suppression amid people with HIV. This investigate is aligned with the NHAS and the EHE initiative’s “Treat” pillar.
For far more details, view CDC’s website page on NOFO PS23-005. Programs are due on 03/22/2023 and can be downloaded from grants.gov.
Extended-Performing Injectables in Non-Clinic Options
Very long-Acting Injectables (LAI) for the Procedure of HIV in Non-Clinic Neighborhood-Based Options will aid study on LAI-Art by utilizing LAI-Art administration in non-clinic configurations. LAI-Art provides several prospective rewards around each day oral treatment method these kinds of as improved benefit, adherence, and treatment method fulfillment. Limitations and difficulties exist with implementation of LAI-Art into present-day health care follow, the two in logistics and in equity. Some of these boundaries may possibly be conquer by using non-clinic websites, these as neighborhood pharmacies, to administer LAI-Art. A multi-website effectiveness-implementation investigation review, designed to compare getting LAI-Artwork in non-clinic community configurations with the oral normal-of-care HIV medical therapy, need to present a special resource of information for enhancing acceptability, availability, and uptake of LAI-Art. Implementation outcomes of fascination contain acceptability, perceived limitations and facilitators, feasibility, and sustainability. Wellbeing outcomes of desire include skipped visits, on-time receipt of injections, and the HIV treatment continuum, like retention in care and viral load suppression. Used qualitative and quantitative study ensuing from this funding is expected to fortify adherence to Art and is aligned with the NHAS and the EHE initiative’s “Treat” pillar.
For much more information, perspective CDC’s web page on NOFO PS23-004. Apps are owing on 02/27/2023 and can be downloaded from grants.gov.
Medical Distrust Between Hispanic/Latino MSM
Determining and Addressing Historic and Structural Drivers of Health care Mistrust (MM) amongst Hispanic/Latino Gay, Bisexual and Other Adult males Who Have Sexual intercourse with Adult males (HLMSM) for HIV Prevention targets EHE initiative jurisdictions with massive Hispanic/Latino populations (30% or additional centered on 2020 US Census data) and will guidance study that captures versions in healthcare distrust drivers amid distinct Hispanic/Latino subgroups (e.g., Central Us residents, Mexicans, Puerto Ricans, US-born, non-US-born, 1st generation, 2nd era). The root triggers for MM in Hispanic/Latino populations in the United States are understudied. MM is a social determinant of health and fitness linked with HIV disparities inside HLMSM (e.g., very low PrEP willingness and adherence) that helps prevent and delays accessibility and engagement in HIV avoidance and care companies (such as PrEP, Artwork). The very little exploration on MM among the HLMSM has neither utilized a heterogeneous H/L population with unique ethnic teams (e.g., Cuban, Mexican, Puerto Rican), nor tackled the historic roots and relevance of MM to health care obtain. Grounded in community-based mostly participatory investigation (CBPR) rules, the objectives of this 2-period NOFO are to: 1) establish MM drivers in HLMSM and present interventions that establish rely on in health providers by means of formative investigate (Section 1) and (2) consider implementation of targeted multilevel interventions that make belief in health expert services (Period 2).
For additional details, view CDC’s site on NOFO PS23-006. Programs are because of on 02/23/2023 and can be downloaded from grants.gov.
Telehealth to Assistance Retention and Adherence to Artwork
Maximizing Telehealth Techniques to Assist Retention and Adherence to Antiretroviral Treatment will aid investigate on proof of usefulness of TeleART by utilizing a hybrid efficiency-implementation investigation study. Telehealth solutions this sort of as TeleART are becoming additional commonly applied on the other hand, to day, there is a dearth of evidence of success of TeleART for Art adherence and retention in HIV treatment in the U.S. The study analysis supported by this NOFO must:
- examine the efficiency of an improved telehealth software for servicing of HIV treatment adherence amid clinically stable people today with HIV (PWH) establish probable implementation facilitators and problems by evaluating the delivery of these strategies and
- evaluate the value and charge-success of furnishing telehealth to people on Artwork, and evaluate program enhancements that include, but may not be restricted to, biospecimen sample self-assortment and the use of specialized workers this sort of as local community health and fitness staff and client navigators.
This enhanced telehealth application should emphasis on teams disproportionately affected by HIV and other people for whom social determinants of well being (e.g., stigma, discrimination, poverty, and reduced socioeconomic position) restrict their engagement in HIV treatment and treatment method. Precisely, African American cis-gender gals, and/or Black or Hispanic/Latino gay, bisexual and other gentlemen who have sexual intercourse with gentlemen, and/or transgender girls, are teams of interest. The study supported by this NOFO must align with the NHAS and the EHE initiative’s “Treat” pillar.
For additional information, watch CDC’s website page on NOFO PS23-002. Programs are due on 03/17/2023 and can be accessed from grants.gov.